Material Safety Data Sheet
Buffer Solution (Acetate) pH 4.00
ACC# 03485
Section 1 - Chemical Product and Company Identification |
MSDS Name: Buffer Solution (Acetate) pH 4.00
Catalog Numbers:
SB85-1
Synonyms:
None
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
|
CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
64-19-7 |
Acetic acid |
47.8 | 200-580-7 |
7732-18-5 |
Water |
28.0 | 231-791-2 |
127-09-3 |
Sodium acetate |
24.4 | 204-823-8 |
50-00-0 |
Formaldehyde |
0.05 | 200-001-8 |
67-56-1 |
Methyl alcohol |
0.02 | 200-659-6 |
Section 3 - Hazards Identification
|
EMERGENCY OVERVIEW
Appearance: clear, colorless liquid.
Danger! Causes eye and skin burns. Causes
digestive and respiratory tract burns. May be harmful if absorbed
through the skin.
Target Organs: Teeth, eyes, skin, mucous
membranes.
Potential Health Effects
Eye:
Causes eye burns. May cause chemical conjunctivitis.
Skin:
Causes skin burns. May cause skin sensitization, an allergic
reaction, which becomes evident upon re-exposure to this material.
May be harmful if absorbed through the skin.
Ingestion:
Causes gastrointestinal tract burns. May cause gastric disturbances
and electrolytic imbalance.
Inhalation:
May cause allergic respiratory reaction. Causes chemical burns to
the respiratory tract. Can produce delayed pulmonary edema.
Chronic:
Chronic exposure to acetic acid may cause erosion of dental enamel,
bronchitis, eye irritation, darkening of the skin, and chronic
inflammation of the respiratory tract. Chronic exposure may cause
effects similar to those of acute exposure.
Section 4 - First Aid Measures
|
Eyes:
Get medical aid. Do NOT allow victim to rub eyes or keep eyes closed.
Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid. Immediately flush skin with plenty of water for at
least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If breathing
is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth
resuscitation. If breathing has ceased apply artificial respiration
using oxygen and a suitable mechanical device such as a bag and a
mask.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
|
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: Not applicable.
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 3; Flammability: 0; Instability: 0
Section 6 - Accidental Release Measures
|
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately,
observing precautions in the Protective Equipment section. Provide
ventilation.
Section 7 - Handling and Storage
|
Handling:
Remove contaminated clothing and wash before reuse. Use only in a
well-ventilated area. Do not breathe dust, vapor, mist, or gas. Do
not get in eyes, on skin, or on clothing. Keep container tightly
closed. Do not ingest or inhale. Wash clothing before reuse. Discard
contaminated shoes.
Storage:
Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances.
Section 8 - Exposure Controls, Personal Protection
|
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
Acetic acid
|
10 ppm TWA; 15 ppm STEL
|
10 ppm TWA; 25 mg/m3 TWA 50 ppm IDLH
|
10 ppm TWA; 25 mg/m3 TWA
|
Water
|
none listed
|
none listed
|
none listed
|
Sodium acetate
|
none listed
|
none listed
|
none listed
|
Formaldehyde
|
0.3 ppm Ceiling
|
0.016 ppm TWA 20 ppm IDLH
|
0.75 ppm TWA; 2 ppm STEL; 0.5 ppm Action Level (Irritant and potential cancer ha zard - see 29 CFR 1910.1048)
|
Methyl alcohol
|
200 ppm TWA; 250 ppm STEL; Skin - potential significant contribution to overall exposure by the cutaneous r oute
|
200 ppm TWA; 260 mg/m3 TWA 6000 ppm IDLH
|
200 ppm TWA; 260 mg/m3 TWA
|
OSHA Vacated PELs:
Acetic acid:
10 ppm TWA; 25 mg/m3 TWA
Water:
No OSHA Vacated PELs are listed for this chemical.
Sodium acetate:
No OSHA Vacated PELs are listed for this chemical.
Formaldehyde:
3 ppm TWA (unless specified in 1910.1048)
Methyl alcohol:
200 ppm TWA; 260 mg/m3 TWA
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
Section 9 - Physical and Chemical Properties
|
Physical State: Liquid
Appearance: clear, colorless
Odor: none reported
pH: 4.00
Vapor Pressure: Not available.
Vapor Density: 0.7
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:Not available.
Decomposition Temperature:Not available.
Solubility: Soluble.
Specific Gravity/Density:1.0-1.2
Molecular Formula:Mixture
Molecular Weight:Not available.
Section 10 - Stability and Reactivity
|
Chemical Stability:
Stable at room temperature in closed containers under normal storage
and handling conditions.
Conditions to Avoid:
Excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, acetic anhydride, ammonium nitrate, chlorine
trifluoride, nitric acid, permanganates, sodium hydroxide, sodium
peroxide, hydrogen peroxide, acetaldehyde, chlorosulfonic acid,
oleum, potassium hydroxide, bromine pentafluoride, perchloric acid,
chromic anhydride, potassium tert-butoxide, ethyleneimine,
2-aminoethanol, ethylene diamine, phosphorus trichloride, phosphorus
isocyanate, diallyl methyl carbinol + ozone, nitric acid + acetone,
xylene, chromic acid.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - Toxicological Information
|
RTECS#:
CAS# 64-19-7:
AF1225000
CAS# 7732-18-5:
ZC0110000
CAS# 127-09-3:
AJ4300010
CAS# 50-00-0:
LP8925000
CAS# 67-56-1:
PC1400000
LD50/LC50:
CAS# 64-19-7:
Draize test, rabbit,
skin: 50 mg/24H Mild;
Inhalation,
mouse: LC50 = 5620 ppm/1H;
Oral,
rat: LD50 = 3310 mg/kg;
Skin,
rabbit: LD50 = 1060 uL/kg;
.
CAS# 7732-18-5:
Oral, rat:
LD50 = >90 mL/kg;
.
CAS# 127-09-3:
Draize test,
rabbit, eye: 10 mg Mild;
Draize
test, rabbit, skin: 500 mg/24H Mild;
Inhalation, rat: LC50 = >30
gm/m3/1H;
Oral, mouse: LD50 = 6891
mg/kg;
Oral, rat: LD50 = 3530
mg/kg;
Skin, rabbit: LD50 = >10
gm/kg;
.
CAS# 50-00-0:
Draize test,
rabbit, eye: 750 ug/24H Severe;
Draize test, rabbit, eye: 750 ug
Severe;
Draize test, rabbit, eye:
10 mg Severe;
Draize test, rabbit,
eye: 37% Severe;
Draize test,
rabbit, skin: 2 mg/24H Severe;
Draize test, rabbit, skin: 50 mg/24H
Moderate;
Inhalation, mouse: LC50 =
454 mg/m3/4H;
Inhalation, mouse:
LC50 = 505 mg/m3/2H;
Inhalation,
rat: LC50 = 203 mg/m3;
Inhalation,
rat: LC50 = 578 mg/m3/2H;
Inhalation, rat: LC50 = 250
ppm/2H;
Oral, mouse: LD50 = 42
CAS# 67-56-1:
Draize test,
rabbit, eye: 40 mg Moderate;
Draize
test, rabbit, eye: 100 mg/24H Moderate;
Draize test, rabbit, skin: 20 mg/24H
Moderate;
Inhalation, rabbit: LC50
= 81000 mg/m3/14H;
Inhalation, rat:
LC50 = 64000 ppm/4H;
Oral, mouse:
LD50 = 7300 mg/kg;
Oral, rabbit:
LD50 = 14200 mg/kg;
Oral, rat:
LD50 = 5600 mg/kg;
Skin, rabbit:
LD50 = 15800 mg/kg;
.
Carcinogenicity:
CAS# 64-19-7:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 7732-18-5:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 127-09-3:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 50-00-0:
- ACGIH:
A2 - Suspected Human Carcinogen
- California:
carcinogen, initial date 1/1/88 (gas)
- NTP:
Suspect carcinogen
- IARC:
Group 1 carcinogen
CAS# 67-56-1:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No data available.
Teratogenicity:
No data available.
Reproductive Effects:
No data available.
Mutagenicity:
No data available.
Neurotoxicity:
No data available.
Other Studies:
Section 12 - Ecological Information
|
Ecotoxicity:
Fish: Bluegill/Sunfish: LC50 = 75 mg/L; 96 Hr; CAS# 64-19-7:
Unspecified
Fish: Goldfish: LC50 = 423 mg/L; 24 Hr; CAS# 64-19-7:
Unspecified
Water flea Daphnia: EC50 = 32-47 mg/L; 24-48 Hr; CAS#
64-19-7: Unspecified
Bacteria: Phytobacterium phosphoreum: EC50 =
8.86-11 mg/L; 5,15,25 min; CAS# 64-19-7: Microtox test
Fish:
Fathead Minnow: LC50 = 88 mg/L; 96 Hr; CAS# 64-19-7: Static bioassay
@ 18-22°C
Fish: Pseudomonas putida:
Section 13 - Disposal Considerations
|
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series:
CAS# 50-00-0: waste
number U122.
CAS# 67-56-1: waste number U154
(Ignitable waste).
Section 14 - Transport Information
|
|
US DOT |
Canada TDG |
Shipping Name: |
ACETIC ACID SOLUTION |
No information available. |
Hazard Class: |
8 |
|
UN Number: |
UN2790 |
|
Packing Group: |
III |
|
Section 15 - Regulatory Information
|
US FEDERAL
TSCA
CAS# 64-19-7 is listed on the TSCA inventory.
CAS# 7732-18-5 is listed on the TSCA inventory.
CAS# 127-09-3 is listed on the TSCA inventory.
CAS# 50-00-0 is listed on the TSCA inventory.
CAS# 67-56-1 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 64-19-7: 5000 lb final RQ; 2270 kg final RQ
CAS# 50-00-0: 100 lb final RQ; 45.4 kg final RQ
CAS# 67-56-1: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
CAS# 50-00-0: 500 lb TPQ
SARA Codes
CAS # 64-19-7: immediate, delayed, fire.
CAS # 50-00-0: immediate, delayed.
CAS # 67-56-1: immediate, fire.
Section 313
Formaldehyde is not at a high
enough concentration to be reportable under Section 313.
Methyl alcohol is not at a high
enough concentration to be reportable under Section 313.
No chemicals are reportable under Section 313.
Clean Air Act:
CAS# 50-00-0 is listed as a hazardous air pollutant (HAP).
CAS# 67-56-1 is listed as a hazardous air pollutant (HAP).
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 64-19-7 is listed as a Hazardous Substance under the CWA.
CAS# 50-00-0 is listed as a Hazardous Substance under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
CAS# 50-00-0 is considered highly hazardous by OSHA.
STATE
CAS# 64-19-7 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# 7732-18-5 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
CAS# 127-09-3 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
CAS# 50-00-0 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# 67-56-1 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
California Prop 65
WARNING: This product contains Formaldehyde, a chemical known to the
state of California to cause cancer.
California No Significant Risk Level:
CAS# 50-00-0: 40 æg/day NSRL
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 23 Do not inhale gas/fumes/vapour/spray.
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
WGK (Water Danger/Protection)
CAS# 64-19-7: 1
CAS# 7732-18-5: No information available.
CAS# 127-09-3: 1
CAS# 50-00-0: 2
CAS# 67-56-1: 1
Canada - DSL/NDSL
CAS# 64-19-7 is listed on Canada's DSL List.
CAS# 7732-18-5 is listed on Canada's DSL List.
CAS# 127-09-3 is listed on Canada's DSL List.
CAS# 50-00-0 is listed on Canada's DSL List.
CAS# 67-56-1 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of E.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 64-19-7 is listed on the Canadian Ingredient Disclosure List.
CAS# 50-00-0 is listed on the Canadian Ingredient Disclosure List.
CAS# 67-56-1 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
|
MSDS Creation Date: 7/22/1999
Revision #5 Date: 11/07/2003
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.